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Plasma Ceramides Predict The Risk Of Myocardial Infarction

Plasma ceramides

Plasma ceramides predict the risk of myocardial infarction, coronary revascularization, acute coronary syndrome hospitalization and mortality within 5 years.

Ceramide risk score

Elevated plasma ceramides are associated with an increased risk of myocardial infarction, acute coronary syndromes, and mortality within 1–5 years. The Score is based on trial data including >4000 subjects.

Ceramide score Risk category

0–2 Lower

3–6 Moderate

7–9 Increased

10–12 Higher

Risk conferred by plasma ceramides is independent of low-density lipoprotein (LDL) cholesterol, C-reactive protein, LDL particles, and lipoprotein-associated phospholipase A2.

Plasma ceramides can be lowered by diet, exercise, simvastatin, rosuvastatin, and proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors

This test measures the levels of ceramides in the blood. All cells make ceramides. They play a big role in the way many types of tissue grow, work and die. Ceramides are linked to atherosclerosis.

Three ceramides have been linked to plaque buildup in the arteries and insulin resistance, which can lead to type 2 diabetes. High levels of these ceramides in the blood are a sign of a higher risk of getting heart disease in 1 to 5 years.

Inputs Courtesy: ENT Specialist Doctor with 41 years of experience. He can be reached Only on  WhatsApp messages at 9243301223.

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